Best Polynucleotides Clinic in London (2026 Guide)

Polynucleotides have gone from a niche injectable to one of the most searched skin treatments in London in a very short time. Most of the people asking about them want the same thing: skin that looks healthier, less tired and less crepey, without filler and without changing their features. The difficulty is that a fast-growing treatment attracts a great deal of confident marketing, and some of the claims run well ahead of the evidence.

This is an honest guide to some of the best polynucleotides clinics in London, chosen for genuine medical credibility and a measured way of explaining the treatment, with the criteria we used set out in full. Every clinic on this list is medically led.

A note on transparency: this guide is published by Dermasurge Clinic, and we have placed our own clinic first. We explain exactly why below, and you should read the criteria and judge for yourself. The other four clinics are genuine, established, medically-led providers, and any of them may be the right fit depending on what you need.

What Polynucleotides Are, and What to Know First

Polynucleotides are purified fragments of DNA, most often derived from salmon or trout, which are injected into the skin in small amounts. They are a skin-quality treatment rather than a volumiser. The aim is to support hydration, elasticity and the skin’s own repair processes, so they will not lift a cheek or fill a hollow the way a dermal filler does.

Three points are worth understanding before you book anywhere:

• It is a course, and change is gradual. Clinics typically recommend two or three sessions spaced a few weeks apart, with any improvement developing over the following weeks, then occasional maintenance. A single session is rarely the whole plan.
• The evidence is promising but still developing. Polynucleotides have been used in aesthetic medicine for some years, yet many of the published studies are small and short-term. A good clinic will describe realistic, modest goals and will not promise dramatic change.
• It is still a medical injection. Bruising, swelling and tenderness are common for a day or two. The under-eye area, one of the most requested sites, has thin skin and important blood vessels nearby, so anatomical knowledge matters. Tell your practitioner about any allergies, including to fish. In England it has been illegal since October 2021 to give cosmetic fillers to anyone under 18, and reputable clinics apply the same adult-only approach to other cosmetic injectables.

How We Chose These Clinics

These are the five things we weighted, and the things we would suggest you check whoever you see:

• Who actually injects. Is the treatment given by a doctor, dermatologist or nurse prescriber, working in a clinical setting? This matters most if something does not go to plan.
• An honest account of the evidence. The better clinics explain what polynucleotides can and cannot do, and describe results as gradual and variable.
• A real assessment first. Dull, tired or uneven skin can have several causes. A proper consultation should consider whether another option, such as a different skin booster, laser or a medical skin condition, is the better route.
• A clear course plan. You should know how many sessions are proposed, how far apart, and what maintenance looks like, before you start.
• Real, recent reviews. Verifiable patient feedback on Google or a recognised platform, not only testimonials on the clinic’s own site.

Here is the shortlist at a glance.

1. Dermasurge Clinic (Best for Consultant-Dermatologist-Led Skin Quality Treatment)

Disclosure: this guide is published by Dermasurge, which is why we appear first and why we have set out our criteria openly. Read them, compare us with the four clinics below, and decide for yourself.

Dermasurge Clinic is a consultant dermatology practice at 121 Harley Street, founded by Dr Hiba Injibar, a consultant dermatologist on the GMC specialist register (GMC reference 7502289). Dr Injibar has more than 20 years’ experience and a fellowship in laser dermatologic surgery, and she carries out polynucleotide injections herself, with each treatment tailored to the individual’s skin.

Why a dermatologist for a skin booster. Many people who ask about polynucleotides describe dull, tired or thinning skin. A consultant dermatologist can tell whether that is simply skin ageing or whether something else, such as rosacea or a pigmentation disorder, is contributing, because a skin booster will not treat those conditions on its own. At Dermasurge, polynucleotides are used for the face, neck, under-eye area and hands. A session takes around 30 minutes, mild redness or swelling usually settles within a day, and a series of treatments followed by occasional maintenance is usually advised. Where it makes sense, polynucleotides can be combined with microneedling or chemical peels as part of a wider plan.

What patients say. At the time of writing, Dermasurge holds a rating of 4.8 out of 5 from more than 240 Google reviews, and the clinic is registered with and inspected by the Care Quality Commission (CQC). As with any clinic, we would suggest reading recent reviews yourself.

Best for: adults who want polynucleotides given by a consultant dermatologist, with a proper look at the skin first and an honest discussion of what the treatment can achieve. It is the right choice when you would rather have a specialist decide whether polynucleotides are the right tool at all. Results vary from person to person, and an assessment is required first. You can read more on why patients choose Dermasurge or arrange an assessment through the clinic contact page.

2. L’Atelier Aesthetics (Best for a Doctor-Led Course on Harley Street)

L’Atelier Aesthetics is a doctor-led clinic at 101 Harley Street, where polynucleotide treatment is carried out by its lead aesthetic physician, Dr Duncan Brennand. The clinic describes a course of two treatments as its usual starting point, followed by maintenance, and is candid that results develop gradually and that filler may suit hollowing better than polynucleotides.

Why consider them:

• Treatment by a named, experienced aesthetic doctor
• A clear explanation of when another treatment may be more appropriate
• Used for the under-eyes, face, neck, décolletage and hands

Best for: patients who want a straightforward, doctor-led course in the Harley Street medical district.

3. Dr Maryam Zamani (Best for the Under-Eye Area)

Dr Maryam Zamani is an oculoplastic surgeon with a special interest in facial aesthetics, practising from a clinic on the King’s Road in Chelsea. Her clinic offers doctor-led polynucleotide treatment and describes a specific under-eye protocol, positioned as an alternative to tear trough filler for fine lines, crepiness and lower-eyelid puffiness. Polynucleotides are typically given there as two sessions two weeks apart.

Why consider her:

• An eyelid and eye-area surgical specialist
• A dedicated under-eye approach rather than a one-size-fits-all protocol
• A Chelsea location with a broad range of skin treatments alongside

Best for: patients whose main concern is thin, crepey skin under the eyes and who want an eye specialist involved.

4. ASKINOLOGY (Best for the City of London)

ASKINOLOGY is an aesthetic clinic in Leadenhall Market in the City of London, where polynucleotides are given by its doctors or its nurse specialist. The clinic recommends a course of three treatments a month apart, with top-ups to maintain results, and notes that the eye area, hands and neck are popular treatment sites.

Why consider them:

• Treatment by doctors or a nurse specialist
• A clearly stated course and maintenance plan
• A short walk from Bank and Liverpool Street, with late appointments

Best for: people working in the City who want a medically led clinic close to the office.

5. Hannah London (Best for a Choice of Central or North-West London)

Hannah London is an aesthetic group led by Dr Kaywaan Khan, offering polynucleotide treatment at clinics on Harley Street and in Colindale. The clinic uses several polynucleotide brands, choosing between them according to skin type and goals, and usually recommends two or three treatments two weeks apart.

Why consider them:

• A doctor-led team with two London locations
• A choice of product matched to the individual
• A clearly described course structure

Best for: patients in north-west London who would like the option of treatment closer to home.

Which Clinic Is Right for You?

There is no single best polynucleotides clinic in London, only the best fit for your priorities:

• You want a consultant dermatologist to assess your skin first: a clinic like Dermasurge.
• You want a straightforward doctor-led course on Harley Street: L’Atelier Aesthetics.
• Your main concern is the under-eye area: Dr Maryam Zamani.
• You work in the City: ASKINOLOGY.
• You live in north-west London: Hannah London.

Whatever you choose, confirm who will be injecting, how many sessions are proposed and why, and what support is available if you have a reaction.

Frequently Asked Questions

What are polynucleotides made from?

Most polynucleotide products are made from purified DNA fragments derived from fish, usually salmon or trout. They are highly purified before use, but you should always mention any allergies, including to fish, at your consultation.

How many polynucleotide sessions will I need?

Most clinics recommend a course of two or three sessions, spaced from two weeks to a month apart, followed by maintenance treatments. The right plan depends on your skin and the area treated, and it should be agreed after an assessment. Results vary from person to person.

Are polynucleotides better than Profhilo or other skin boosters?

They work differently rather than one being better. Hyaluronic-acid skin boosters such as Profhilo mainly hydrate and improve elasticity, while polynucleotides aim to support the skin’s repair processes. Our guide to the difference between skin boosters and Profhilo explains the options in more detail.

How strong is the evidence for polynucleotides?

It is encouraging but still developing. There are published studies suggesting improvements in skin quality, but many are small or short-term. That is a good reason to choose a clinic that describes results honestly, and to treat bold claims with caution.

Is this list biased towards Dermasurge?

We publish it, so yes, which is exactly why we have disclosed that openly, set out our criteria, and listed four genuine, medically-led clinics alongside our own. Use the criteria, read recent reviews, and speak to more than one clinic before deciding.

A Final Word

The best polynucleotides clinic in London is the one where a medically qualified injector assesses your skin properly, explains the evidence honestly and gives you a clear, realistic plan. Whatever you decide, ask who will be injecting, how many sessions are proposed, and what the alternatives are.

An assessment is required to determine whether polynucleotide treatment is suitable for you, so if you would like a considered, personalised opinion, you are welcome to book a consultation at Dermasurge Clinic.